Through years of clinical observation and deep research into the mechanisms of aging, experts have identified that facial volume loss is primarily driven by three key factors:
- Collagen Damage: The stiffening and disorganization of collagen fibers, triggered by a process called glycation.
- Collagen Depletion: A significant decline in skin's collagen quantity.
- Loss of Structural Support: The progressive depletion of glycosaminoglycans and collagens, which are essential molecules that sustain the matrix network.
To prove the efficacy of the REPLASTY AGE RECOVERY DAY [GR] cream, Helena Rubinstein has pushed the boundaries of Cellular Skin ScienceTM. The cream’s performance was rigorously evaluated through a groundbreaking ex-vivo study on skin explants, utilizing state-of-the-art technologies.
Decaramelization of collagen fibers
Scientific results are undeniable: Replasty Age Recovery Day [GR] acts as an anti-glycation shield which directly contributes to preserving skin’s original suppleness.
After 8 days, the unprecedented Triple Collagen Intervention (including PRO-XYLANE™ + GLYCO-REVERSE™) prevents and blocks 100% of the glycation process in the upper layers of the dermis (papillary dermis and upper reticular dermis) and even reverse it.
In the deeper dermis, the product reduces "caramelization" marker CML (an Advanced Glycation End Product, also called ‘AGE’) by up to -82%.
Decaramelizing efficacy of Replasty Age Recovery Day [GR]
Glycated skin (glycation in darker pink)
Glycated skin treated with Replasty Age Recovery [GR]
Multiplication: Unprecedented Collagen Synthesis
Thanks to the exceptional concentration of Pro-Xylane™, an iconic molecule resulting from more than 25 years of research, Replasty Age Recovery Day [GR] does not merely stimulate a single type of collagen. It boosts the synthesis of 11 major collagen families across all skin layers.
The study demonstrates spectacular increases:
- Collagen I : +71% (the skin’s most abundant collagen)
- Collagen V: +247% (essential for structure).
- Collagen VI: +121% (key for collagen network assembly).
This multiplication of collagen chains contributes to the restoration of dermal density and volume.
Collagen multiplying efficacy of Replasty Age Recovery Day [GR]
Glycated skin
Glycated skin treated with Replasty Age Recovery Day [GR] (collagen in darker pink)
Remodeling: Engineering the Skin Network
Simply producing new collagen isn't enough. For youthful skin full of volume, those fibers must be well organized. The new Replasty Age Recovery Day [GR] achieves this by stimulating crucial structural proteins, boosting Laminin-5 by +97% and Fibrillin-1 by +84%.
To prove this structural transformation, Helena Rubinstein utilized Atomic Force Microscopy (AFM) to assess collagen fiber organization. Unlike standard optical microscopes that use light and lenses, AFM doesn't just "look" at the skin—it "feels" it. Using an incredibly tiny, sharp mechanical probe just a few nanometers wide, AFM gently traces the surface of the tissue sample. As the probe encounters the microscopic peaks and valleys of the skin tissue's internal architecture, a tracking laser measures its precise movements to generate an ultra-high-resolution, 3D topographical map.
This advanced nanoscale mapping revealed a +20% improvement in collagen fiber organization after using Replasty Age Recovery Day [GR]. Furthermore, when researchers measured the skin's mechanical resistance—specifically, its ability to bounce back from elastic deformation—they recorded a remarkable +55% increase.
The result proves a collagen network that is remodeled, more resilient, and well aligned.
Collagen remodeling with Replasty Age Recovery Day [GR] evaluated using AFM
Glycated skin (collagen fibers and fibrils disorganized)
Glycated skin treated with Replasty Age Recovery Day [GR] (collagen fibers and fibrils aligned)
The Benefits
By acting on the deep biological structure, Replasty Age Recovery Day [GR] offers comprehensive collagen protection, amplification and remodeling. This directly contributes to restore volumes and smooth wrinkles.
Audrey Gueniche
– Scientific Director
Audrey GUENICHE is a Doctor in Pharmacy and has a PhD in skin biology. She has a distinguished career of over three decades at L’Oréal in Research and Innovation. Her scientific contributions have been in the areas of topical and food supplements of skin, scalp, hair health and beauty. Audrey’s experience is extensive: from vitro to clinical trials, to open innovation and development. She has published over 130 papers in peer-reviewed journals, presented in 80 international congresses and, additionally, has been recognized and guest speaker in 50 plenary conferences. By embracing an innovative mindset, Audrey is passionate in finding new areas to promote actives and formulas, prove new claims and scientific communications, and reinvent evaluations. As HELENA RUBINSTEIN’s Scientific Director, Audrey pursues the brand’s long-standing avant-garde research and science.
